riding/ulcer treatment update

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This week at work was very busy but I did manage to squeeze in a few rides. Everyone wants to know what differences I've seen in Lucy since we started the GastroGard. The biggest difference is that she accepts my leg much better. She occasionally still kicks out, she still bucks, and today she popped a little rear when I didn't let her stop just because she thought she was done, but as far as accepting the forward cue from my legs, she is much better. She also still spooks at nothing, which is not like her and I hope the lyme titer will shed some light on that when it comes back.

Other than accepting my leg, she also seems to be much more chill, not under saddle but just in general. She takes long naps in her paddock in the middle of the day, which she never did before. She doesn't try to run me over on the way from her paddock to the barn in the afternoons. Besides the spooking, she seems less reactionary than before. She demolishes her hay every night and we are actually up to 4 flakes a night, whereas before the treatment, if I gave her any more than 2 flakes, she would not eat it and I would end up having to throw the excess away because she'd poop and pee all over it. Her stall has also been markedly easier to clean, as if she's moving around less at night.

We are just 1/3 of the way through the treatment now and I hope her temperament will even out further as we complete the rest of the GastroGard.

Anyway, we had a lovely ride yesterday and my friend took some photos for me :) I am very happy with the canter work we did. She was really relaxing through her shoulders and topline and it felt lovely.

Indian Patent granted for Lilly's tadalafil

IPO(Chennai) has recently issued an Indian patent IN224314 herein referred to as ‘314 patent to Lilly Icos LLC for cialis particulate form and method of preparation thereof. The said patent is issued against the national phase application (PCT) # IN/PCT/2002/143/CHE claiming priority from US provisional application # 60/147,048 dated August 03, 1999 which later issued as US 6,821,975 and currently listed with the US FDA Orange Book.

Tadalafil is marketed as purchase cialis by Eli Lilly whic was granted EMR in India against the application # 85/DEL/1995 (the 1995 application) which later got stayed by the Calcutta High Court after a petition made by Mumbai-based Ajanta Pharma. The 1995 application covered claims for Tadalafil per se and process of preparation thereof. A pre-grant opposition was filed by Ajanta Pharma at the Indian Patent Office (Delhi) last year on March 22 wherein the IPO rejected the product claims for Tadalafil per se but allowed process claims. The product claims were found obvious over the US 3,917,599 (the ‘599 patent) issued to CDRI. The ‘599 patent exemplified 2-substituted-1, 2, 3, 4, 6, 7, 12, 12a-octahydropyrazino [2’, 1’:6, 1] pyrido [3, 4-b] indoles which is the base structure of Tadalafil but never suggested to be useful for treatment of erectile dysfunction. Pre grant opposition filed for tadalafil can be found here